"Structural and spectrophotometric characterization of biogenic and chemically synthesized systems in interaction with biostructures ", PROTOCOL NO. 462.1-2-17/19

PROTOCOL NO. 462.1-2-17/19
TITLE OF THE GRANT: The effect of proton beam irradiation on the in vitro action of antitumor drugs
THEME: 04-2-1132-2017/2019
YEAR: 2017
LABORATORY IN JINR: Dzelepov Laboratory of uclear Problems (DLNP)
PARTNERS IN ROMANIA: Faculty of Physics, University of Bucharest (FFUB)
RESPONSIBLE PERSONS: Lect. dr. Claudia CHILOM (FFUB), Gennady V. MYTSIN (DLNP)
OBJECTIVES:

• the study of the interaction between bio-mimetic membranes and antitumor drugs irradiated with proton beams accelerated in the Phasotron DLNP, at JINR;
• in vitro testing of antitumor drugs (exposed or unexposed to proton beams) - hemolytic activities;
• in vitro testing of antitumor drugs (exposed or unexposed to hadrons) cytotoxic effects.

EXPECTED RESULTS: Main results expected from this investigation are:

1. the spectroscopic characterization of the interaction between bio-mimetic membranes and antitumor drugs irradiated with proton beam.
2. the investigation of the hemolytic activity by in vitro testing of antitumor drugs (exposed or unexposed to proton beam)
3. the investigation of the cytotoxic effects by in vitro testing of antitumor drugs (exposed or unexposed to hadrons).