Preliminary Results / Progress Reports:

2011 2012 2013 2014 2015 2016

Book Chapters:

• Ciurea A, Mindruta I, Ciurea A, Ciurea J, Barborica A, Donos C, Casanova MF, Opris I, Modular signatures and neural avalanches in epileptic brain networks  In: Recent Advances in the Modular Organization of the Cerebral Cortex. Casanova MF, Opris I, eds. Springer Press, New York, 2015.

Papers:

• Donos C, Mălîia MD, Mîndruţă I, Popa I, Ene M, Bălănescu B, Ciurea A, Barborica A. A connectomics approach combining structural and effective connectivity assessed by intracranial electrical stimulation. Neuroimage. 2016;132:344-358. doi: 10.1016/j.neuroimage.2016.02.054.

• Popa I, Donos C, Barborica A, Opris I, Mălîia MD, Ene M, Ciurea J, Mîndruţă I. Intrusive Thoughts Elicited by Direct Electrical Stimulation during Stereo-Electroencephalography. Front Neurol. 2016 Jul 18;7:114. doi: 10.3389/fneur.2016.00114

• Trebaul L, Rudrauf D, Job AS, Mălîia MD, Popa I, Barborica A, Minotti L, Mîndruţă I, Kahane P, David O. Stimulation artifact correction method for estimation of early cortico-cortical evoked potentials. J Neurosci Methods. 2016 Mar 4;264:94-102. doi: 10.1016/j.jneumeth.2016.03.002.

• Ciurea A, Popa I, Maliia MD, Nagy CJ, Barborica A, Donos C, Ciurea J, Opris I, Mindruta I, Successful epilepsy surgery in frontal lobe epilepsy with startle seizures - a SEEG study, Epileptic Disord. 2015; 17(4):363-371.

• Donos C, Mîndruţă I, Ciurea J, Mălîia MD, Barborica A. A comparative study of the effects of pulse parameters for intracranial direct electrical stimulation in epilepsy. Clin Neurophysiol. 2016; 127:91-101. doi: 10.1016/j.clinph.2015.02.013.

• Craiu D, Barborică A, Moţoescu C, Donos C, Ciurea J, Mîndruţă I, Presurgical evaluation and epilepsy surgery in MRI negative resistant epilepsy of childhood with good outcome, Turkish Neurosurgery 2015;25(6):905-13. doi: 10.5137/1019-5149.JTN.12093-14.0.

• Balanescu, B., Franklin, R., Ciurea, J., Mindruta, I., Rasina A., Bobulescu, R. C., Donos, C., Barborica, A. A Personalized Stereotactic Fixture For Implantation Of Depth Electrodes In Stereoelectroencephalography. Stereotactic and Functional Neurosurgery, 2014;92(2):117-25. DOI:10.1159/000360226

Awards:

• ILAE Epileptic Disorders Educational Prize awarded to Dr Ioana Mindruta for the paper: Successful epilepsy surgery in frontal lobe epilepsy with startle seizures - a SEEG study, Epileptic Disord. 2015; 17(4):363-371. (Link)(Announcement)

Results Presented  at International Academic Events:

• A Vascular Safety Index For Stereotactic Targeting Of Deep Brain Structures, Stereotact Funct Neurosurg 2012; 90 (suppl 1): 1-202, p121, The XXth Congress of the European Society for Stereotactic and Functional Neurosurgery, 2012, Lisbon, Portugal  (Poster)

• A Personalized Stereotactic Fixture For Implantation Of Depth Electrodes In Stereoelectroencephalography (SEEG), American Epilepsy Society 2012 Annual Meeting, San Diego, Epilepsy Currents: January/February 2013, Vol. 13(S1), pp. 1-492. (Abstract) (Poster)

• Stimulus Amplitude Effect In Time And Frequency On Responses To Single Pulse Electrical Stimulation In Stereoelectroencephalographic Studies, The 30th International Epilepsy Congress, Montreal, Canada, 23–27 June, 2013, Epilepsia, 54(Suppl. 3):267–268, 2013. (Abstract) (Poster)

• Mapping Cortical Excitability Using Single Pulse Electrical Stimulation in Stereoelectroencephalographic Studies, American Epilepsy Society 2013 Annual Meeting, 6-10 December 2013 ,Washington DC, USA,  Epilepsy Currents: January/February 2014, Vol. 14(S1), pp. 1-475  (Abstract) (Poster)

• Stereoelectroencephalographic 3-D mapping of epileptogenicity using responses to single-pulse electrical stimulation, International Neurophysiology Congress 2014, Berlin, Germany  (Poster)

• Maliia MD; Barborică A; Donos C; Ciurea J; Balanescu B; Rasina A; Mîndruţă I; Anatomofunctional mapping of the opercular cortex by intra-cerebral electrical stimulations in epileptic patients explored by means of stereoelectroencephalography (SEEG), International Neurophysiology Congress, 20-23 March 2014, Berlin, Germany (Poster)

• Maliia MD; Barborică A; Donos C; Ciurea J; Mîndruţă I, Ictal offset patterns and postictal dynamics - a SEEG study, The 11th European Epilepsy Congress, 29th June – 3rd July 2014, Stockholm, Sweden (Presentation) 

• Single-unit activity evoked by electrical stimulation of human epileptogenic cortex. Society for Neuroscience 2014, 15th-19th November 2014,  Washington DC, USA (Poster)  

• Ioana Mindruta1, Lorella Minotti, Anne Sophie Job, Dominique Hoffmann, Stephan Chabardes, Andrei Barborica, Jean Ciurea and Philippe Kahane. Networks Of Laughing Seizures - A Stereoelectroencephalographic Study. AES 2014 Annual Meeting Online Abstract Supplement. Epilepsy Currents: January/February 2015, Vol. 15, No. S1, pp. 86. doi: http://dx.doi.org/10.5698/1535-7597-15.s1.1

• Andrei Barborica Cristian Donos, Mihai Maliia, Jean Ciurea, Alin Rasina and Ioana Mindruta. How Reliable Are The High-Frequency Oscillations And Delayed Responses As Epileptogenicity Biomarkers? A Study Based On Intracranial Stimulation (2015) AES 2014 Annual Meeting Online Abstract Supplement. Epilepsy Currents: January/February 2015, Vol. 15, No. S1, pp. 419-420. doi: http://dx.doi.org/10.5698/1535-7597-15.s1.1

• Maliia MD, Donos C, Barborica A, Popa I, Ene M, Gheorghiu A., Mindruta I. The interictal effective connectivity of the frontal seizure onset zone revealed by single pulse electrical stimulations in stereoelectroencephalography, 8th International Epilepsy Colloquium, 14th-17th June 2015, Grenoble, France.

• Andrei Barborica. Technologic advances in invasive monitoring: Using hybrid electrodes, 8th International Epilepsy Colloquium, 14th-17th June 2015, Grenoble, France. - invited talk

• Andrei Barborica, Cristian Donos, Ioana Mindruta, Jean Ciurea. Time-locking of single-unit activity to electrical stimulation: a possible signature of human epileptogenic cortex, Brain States: Characterization and Neuromodulation by DBS, 11th-13th November 2015, Koln, Germany (Poster)

• Cristian Donos, Mihai Maliia, Ioana Mindruta, Jean Ciurea, Laura Craciun, Andrei Barborica. A physiological connectome of the human brain, based on intracranial electrical stimulation, International Epilepsy Congress, 5th-9th September 2015, Istanbul, Turkey (Poster)

• Mihai Dragos Maliia, Cristian Donos, Andrei Barborica, Irina Popa, Jean Ciurea, Laura Craciun, Ioana Mindruta. Seizure onset zone effective connectome as revealed by single pulse electrical stimulation in stereoencephalographic studies, International Epilepsy Congress, 5th-9th September 2015, Istanbul, Turkey (Poster)

• Maliia MD, Donos C, Barborica A, Popa I, Ene M, Ciurea J, Mindruta I. Introducing the epileptome-dynamic seizure onset zone (SOZ) connectome as revealed by single pulse electrical stimulation(SPES)in stereoelectroencephalography (SEEG), The 15th Congress of Clinical Neurophysiology, 30th September - 3rd October 2015, Brno, Czech Republic (Presentation)

• Evoked potentials in invasive EEG: a method with potential? German Epilepsy Society, 22nd-24th April 2015. (Presentation)

• Andrei Barborica. New developments in recording and analyzing HFOs: Depth Electrodes. The 2nd International Workshop on High Frequency Oscillations in Epilepsy, March 10th-12th, 2016, Freiburg, Germany. - invited talk

• Cristian Donos. Automatic HFO detector based on time-frequency representations and computer vision. ITe 2nd International Workshop on High Frequency Oscillations in Epilepsy, March 10th-12th, 2016, Freiburg, Germany. - invited talk

• Cristian Donos, Ioana Mindruta, Mihai Dragos Maliia, Irina Popa, Anca Arbune, Sabina Ene, Jean Ciurea, Andrei Barborica. A computer vision approach to automatic detection of high frequency oscillations. The 2nd International Workshop on High Frequency Oscillations in Epilepsy, March 10th-12th, 2016, Freiburg, Germany. (Poster)
  
  

National Academic Events:

• SEEG in Presurgical Evaluation of Focal Epilepsy, ASNER National Conference, 2012 (Presentation)

• Electroencefalografia intracraniana stereotactica ca metoda de evaluare prechirurgicala in epilepsie. Prezentare de caz. Al X-lea Congres al Societatii de Neurologie din Romania, Bucharest 2012

• What We Have Learned from Intracranial Direct Electrical Stimulation (SEEG Studies), Therapeutic Options in Pharmacoresistant Epilepsy, Bucharest 2013 (Presentation)

• Refractory Posterior Epilepsy - Romanian Cases in Adults, Therapeutic Options in Pharmacoresistant Epilepsy, Bucharest 2013

• Intracranial stimulation studies of brain connectivity in epilepsy,  4th Conference of the National Neuroscience Society of Romania, IBRO symposium “Abnormal Brain Connectivity”, Bucharest, October 17th-19th 2013, (Presentation), (Supplementary Material: HFO 3D Map Animation, Delayed Responses 3D Map Animation)

• A physiological effective connectome of the human brain, based on intracranial electrical stimulation, The 6thSummer School of ASNER, The Romanian Society of Electrodiagnostic Neurophysiology, 10th-11th July 2015, Eforie, Romania (Presentation)

• A physiological connectome of the human brain based on intracranial electrical stimulation in patients with epilepsy, 
  Optiuni terapeutice in epilepsia farmacorezistenta, 23rd-25th April 2015, Bucharest, Romania (Presentation)

• Microelectrode recordings in the seizure onset zone, Optiuni terapeutice in epilepsia farmacorezistenta, 23rd-25th April 2015, Bucharest, Romania (Presentation)